Clozapine is an atypical antipsychotic medication used primarily for treatment-resistant schizophrenia and schizoaffective disorder. In the U.S., it is also approved for recurrent suicidal behavior in schizophrenia or schizoaffective disorder. It is an oral prescription medicine with established global use.
Researchers identify speech latency as a biomarker to enrich schizophrenia clinical trials, while a separate study finds clozapine more effective than alternatives for patients who fail initial antipsychotic treatment.
Newron Pharmaceuticals has secured up to €38 million in milestone-based financing from European and Asian investors to advance its Phase III ENIGMA-TRS program evaluating evenamide as an add-on therapy for treatment-resistant schizophrenia.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07262736 |
Pharmacokinetics of Clozapine and Norclozapine and the Effect of Pantoprazole |
COMPLETED | PHASE1 |
| NCT07085195 |
A Clinical Study of the Safety and Efficacy of Chemogenetics Therapy in the Treatment of Parkinson's Disease |
NOT_YET_RECRUITING | EARLY_PHASE1 |
| NCT06969755 |
Biomarkers to Enhance Early Schizophrenia Treatment |
RECRUITING | PHASE4 |
| NCT06159322 |
Characterizing Response to Antipsychotics in Schizophrenia |
RECRUITING | |
| NCT06011460 |
Observation of Clozapine Treatment Safety in Bipolar Disorder. |
ENROLLING_BY_INVITATION | |
| NCT05958875 |
The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. |
RECRUITING | PHASE4 |
| NCT05741502 |
An Exploratory Analysis of Immune and Inflammatory Response Associated With Clozapine |
TERMINATED | PHASE4 |
| NCT05603104 |
Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure |
RECRUITING | PHASE3 |
| NCT05316883 |
Biomarkers in Clozapine-responding Schizophrenia |
RECRUITING | PHASE4 |
| NCT05208190 |
Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial |
RECRUITING | PHASE4 |
