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Impact of Cataract Surgery on Keratoplasty Graft Survival

NCT02875145 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 453

Last updated 2016-08-23

No results posted yet for this study

Summary

The follow up time after keratoplasty now routinely exceeds multiple decades. It is common for keratoplasty patients to also undergo cataract surgery at a later date in their lives.

Keratoplasties and cataract surgery both result in local inflammation. This may influence the density of endothelial cells, and on average there is a loss of 10% in endothelial cells within 3 months of the cataract surgery. Yet, a sufficient density of endothelial cells is required to maintain graft transparency. It may be therefore difficult to strike a balance between loss of visual acuity due to the cataract of to the loss of graft transparency over the long term.

The investigators aim to compare graft survival in patients with clear crystalline lens with and without cataract surgery.

Conditions

  • Cataract
  • Fuchs' Endothelial Dystrophy
  • Keratoconus

Interventions

PROCEDURE

Cataract surgery

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Besancon

    lead OTHER

Principal Investigators

  • Bernard Delbosc, MD, PhD · Opthalmology Department, CHU Besançon

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-08-31
Primary Completion
2015-08-31
Completion
2015-08-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02875145 on ClinicalTrials.gov