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Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study

NCT02860975 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 5

Last updated 2026-04-27

Study results available
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Summary

The purpose of this study is to define the safety and the biochemical-physiological response of prolonged exposure to a normobaric low-oxygen environment in healthy volunteers.

Conditions

  • Healthy Volunteers

Interventions

OTHER

Inhaled Nitrogen

To create the correct gas mixture, nitrogen tanks or membrane technology nitrogen generators will be utilized. Humidified, high flow, hypoxic gas by nasal cannula will allow the participant to walk short distances, eat, execute basic personal needs (e.g., use of toilette, washing, bathing etc.), or take breaks from wearing the mask.

Sponsors & Collaborators

  • Rezoagli, Emanuele, M.D., Massachusetts General Hospital, Harvard Medical School

    collaborator UNKNOWN

  • Ferrari, Michele, M.D., Massachusetts General Hospital, Harvard Medical School

    collaborator UNKNOWN

  • Patel, Sarvagna, B.A., Massachusetts General Hospital, Harvard Medical School

    collaborator UNKNOWN

  • Zapol, Warren M., M.D., Massachusetts General Hospital, Harvard Medical School

    collaborator UNKNOWN

  • Fisher, Daniel, R.R.T., Massachusetts General Hospital, Harvard Medical School

    collaborator UNKNOWN

  • Jain, Isha, B.A., Massachusetts General Hospital, Harvard Medical School

    collaborator UNKNOWN

  • Mootha, Vamsi, M.D., Massachusetts General Hospital, Harvard Medical School

    collaborator UNKNOWN

  • Harris, Stuart N., M.D., Massachusetts General Hospital, Harvard Medical School

    collaborator UNKNOWN

  • Karaa, Amel, M.D., Massachusetts General Hospital, Harvard Medical School

    collaborator UNKNOWN

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Lorenzo Berra, MD · Massachusetts General Hospital

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-31
Primary Completion
2019-04-05
Completion
2019-04-05

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02860975 on ClinicalTrials.gov