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Transporter Cocktail Mutual Interaction

NCT02854527 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2023-11-07

Study results available
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Summary

Main objective is to investigate mutual pharmacokinetic drug-drug interactions of digoxin, furosemide, metformin, and rosuvastatin when given all together as a cocktail

Conditions

  • Healthy

Interventions

DRUG

Digoxin

single dose

DRUG

Furosemide

single dose

DRUG

Metformin

single dose

DRUG

Rosuvastatin

single dose

DRUG

Digoxin

0.25 mg digoxin as single dose (all 4 drugs given together as a cocktail at the same time point)

DRUG

Furosemide

1 mg furosemide as single dose (all 4 drugs given together as a cocktail at the same time point)

DRUG

Metformin hydrochloride

10 mg metformin hydrochloride as single dose (all 4 drugs given together as a cocktail at the same time point)

DRUG

Rosuvastatin

10 mg rosuvastatin as single dose (all 4 drugs given together as a cocktail at the same time point)

Sponsors & Collaborators

Principal Investigators

  • Boehringer Ingelheim · Boehringer Ingelheim

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-08-22
Primary Completion
2016-11-11
Completion
2016-11-19

Countries

  • Germany

Study Locations

More Related Trials

Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02854527 on ClinicalTrials.gov