MedTrace Logo

Drug-drug Interaction Between Digoxin, Furosemide, Metformin, and Rosuvastatin

NCT02231931 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2023-10-24

No results posted yet for this study

Summary

To investigate the mutual interaction potential of digoxin, furosemide, metformin, and rosuvastatin when given alone or together as a cocktail, and to investigate the effect of high doses of metformin or furosemide on pharmacokinetics of the other cocktail compounds

Conditions

  • Healthy

Interventions

DRUG

Digoxin

single dose, fasted

DRUG

Rosuvastatin

single dose, fasted

DRUG

Digoxin, Furosemide, Metformin hydrochloride, Rosuvastatin

fasted

DRUG

Digoxin, Furosemide, Metformin hydrochloride, Rosuvastatin

fasted

DRUG

Metformin hydrochloride

single dose, fasted

DRUG

Digoxin, Furosemide, Metformin hydrochloride, Rosuvastatin

fasted

DRUG

Furosemide

single dose, fasted

Sponsors & Collaborators

Principal Investigators

  • Boehringer Ingelheim · Boehringer Ingelheim

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-09-01
Primary Completion
2015-01-01
Completion
2015-01-01

Countries

  • Germany

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02231931 on ClinicalTrials.gov