Evaluation of Prognosis Factors of Neurological Evolution in Cardiac Arrest

Summary

With the repercussion of 55 cases eachyear for 100 000 inhabitants in France, cardio respiratory arrest is a public health issue.

The goal of this study is to evaluate the pupillary light reflex measured by the dimension of the pupil (diameter) as a prognosis factor neurological evolution in post cardiac arrest. By participating to this study, the patient get the same tratments and exams than in a usual managing cares.

In addition of these events, the pupillary light reflex is studied as soon as the patient is accepted in the department, and then on the second day.

Currently, the evaluation of the neurological becoming rely on a multimodal clinical and paraclinical approach.

The study of the pupillary light reflex measured by the diameter of the pupil could be a prognosis factor of neurological evolution for patients in post cardiac arrest, so a reliable and available prognosis marker in patient care.

The goal of this study is to evaluate the pupillary light reflex (RPM), measured by the diameter of the pupil as a prognosis factor of neurological evaluation of admitted patients after a cardiac arrest.

Principal criteria of judgement is the percentage of the pupillary light reflex variation measured with Neurolight®, compared between two groups.

Conditions

• Cardio Respiratory Arrest

Interventions

OTHER

Therapeutic hypothermia

With a mattress at 4°C to reach a central temperature at 33,5°C.

DEVICE

Synchronized Intermittent Mandatory Ventilation

Constant volume 6 ml/kg

OTHER

Electroencephalography

DEVICE

Pupillary light reflex surveillance

With Neurolight® device.

DEVICE

Transcranial Doppler

Monitoring tool for brain hemodynamic evaluation. With Philips HD15 Ultrasound system®.

Sponsors & Collaborators

• University Hospital, Grenoble

  lead OTHER

Principal Investigators

• Michel Durand, Doctor · Grenoble Hospital University

Study Design

Allocation

RANDOMIZED

Masking

DOUBLE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-01-31

Primary Completion

2015-07-31

Completion

2015-07-31

Countries

• France

Study Locations