AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas
NCT02831257 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 18
Last updated 2022-06-13
Summary
The goal of this clinical research study is to learn if the study drug AZD2014 can shrink growing or symptomatic meningiomas.
Conditions
- Neurofibromatosis 2
- Meningioma
Interventions
- DRUG
-
AZD2014
Sponsors & Collaborators
- collaborator INDUSTRY
-
United States Department of Defense
collaborator FED -
Massachusetts General Hospital
lead OTHER
Principal Investigators
-
Scott Plotkin, MD, PhD · Massachusetts General Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2016-08-31
- Primary Completion
- 2019-05-31
- Completion
- 2020-10-01
Countries
- United States
Study Locations
More Related Trials
-
Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma
NCT06894979 ·Status: RECRUITING ·Phase: PHASE1
-
Trabectedin for Recurrent Grade II/III Meningioma
NCT02234050 ·Status: COMPLETED ·Phase: PHASE2
-
AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the Spine
NCT00326872 ·Status: TERMINATED ·Phase: PHASE2
-
Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma
NCT02282917 ·Status: TERMINATED ·Phase: EARLY_PHASE1
-
Fenretinide in Treating Patients With Recurrent Malignant Glioma
NCT00006080 ·Status: COMPLETED ·Phase: PHASE2
-
Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma
NCT00895622 ·Status: COMPLETED ·Phase: PHASE2
-
S9005 Mifepristone in Meningioma
NCT03015701 ·Status: COMPLETED ·Phase: PHASE3
-
High-Dose Methotrexate and Leucovorin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
NCT00082797 ·Status: COMPLETED ·Phase: PHASE2
-
Gliadel Wafer, Temozolomide and Radiation Therapy for Newly Diagnosed GBM
NCT00548938 ·Status: TERMINATED ·Phase: PHASE2
-
Improving the Selection of Patients With Glioblastoma Multiforme for Treatment With Epidermal Growth Factor Receptor Inhibitor Therapies
NCT00897663 ·Status: COMPLETED
-
Prinomastat Plus Temozolomide Following Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
NCT00004200 ·Status: COMPLETED ·Phase: PHASE2
-
Monthly SOM230C for Recurrent or Progressive Meningioma
NCT00859040 ·Status: COMPLETED ·Phase: PHASE2
-
Targeted Pediatric High-Grade Glioma Therapy
NCT05839379 ·Status: RECRUITING
-
Nitrocamptothecin in Treating Patients With Glioblastoma Multiforme
NCT00005826 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms
NCT00004688 ·Status: COMPLETED ·Phase: PHASE2
-
Treatment of Recurrent or Progressive Meningiomas With the Radiolabelled Somatostatin Antagonist 177Lu-satoreotide
NCT04997317 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of Motexafin Gadolinium and Temozolomide for the Treatment of Malignant Gliomas
NCT00080054 ·Status: COMPLETED ·Phase: PHASE1
-
ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Treatment of Recurrent High-Grade Glioma
NCT05917145 ·Status: RECRUITING ·Phase: PHASE1
-
Antineoplaston Therapy in Treating Adult Patients With Anaplastic Astrocytoma
NCT00003537 ·Status: COMPLETED ·Phase: PHASE2
-
Antineoplaston Therapy in Treating Patients With Low-Grade Astrocytoma
NCT00003471 ·Status: TERMINATED ·Phase: PHASE2
-
Temozolomide and Radiation Therapy in Treating Patients With Gliomas
NCT00114140 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase II Study of Adjuvant Use of Anti-Epidermal Growth Factor Receptor EGFR-425 in High Grade Gliomas
NCT00589706 ·Status: COMPLETED ·Phase: PHASE2
-
Radiation Therapy, Temozolomide, and Irinotecan in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
NCT00099125 ·Status: COMPLETED ·Phase: PHASE2
-
AZD2171 in Treating Patients With Recurrent Glioblastoma Multiforme
NCT00305656 ·Status: COMPLETED ·Phase: PHASE2
-
Methotrexate and Thiotepa in Treating Patients With Newly Diagnosed Primary CNS Lymphoma
NCT00045539 ·Status: COMPLETED ·Phase: PHASE2