Improving the Selection of Patients With Glioblastoma Multiforme for Treatment With Epidermal Growth Factor Receptor Inhibitor Therapies
NCT00897663 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 56
Last updated 2018-01-24
Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This laboratory study is looking at tissue samples from patients with glioblastoma multiforme to identify biomarkers that may improve the selection of patients for epidermal growth factor receptor inhibitor therapies.
Conditions
Interventions
- GENETIC
-
gene expression analysis
- GENETIC
-
microarray analysis
- GENETIC
-
protein expression analysis
- OTHER
-
diagnostic laboratory biomarker analysis
- OTHER
-
immunohistochemistry staining method
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Alliance for Clinical Trials in Oncology
lead OTHER
Principal Investigators
-
Jann Sarkaria, MD · Mayo Clinic
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-11-30
- Primary Completion
- 2018-01-31
- Completion
- 2018-01-31
Countries
- United States
Study Locations
More Related Trials
-
A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions
NCT06072586 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma
NCT05879367 ·Status: RECRUITING ·Phase: PHASE1
-
Cellular Adoptive Immunotherapy Using Genetically Modified T-Lymphocytes in Treating Patients With Recurrent or Refractory High-Grade Malignant Glioma
NCT00730613 ·Status: COMPLETED ·Phase: PHASE1
-
G207 Followed by Radiation Therapy in Malignant Glioma
NCT00157703 ·Status: COMPLETED ·Phase: PHASE1
-
RO4929097 in Treating Patients With Recurrent Invasive Gliomas
NCT01269411 ·Status: TERMINATED ·Phase: PHASE1
-
EGFR Inhibition Using Weekly Erlotinib for Recurrent Malignant Gliomas
NCT01257594 ·Status: COMPLETED ·Phase: PHASE1
-
Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors
NCT00025675 ·Status: COMPLETED ·Phase: PHASE2
-
HMPL-813 in Treating Patients With Glioblastoma
NCT03231501 ·Status: UNKNOWN ·Phase: PHASE1
-
GDC-0449 in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery
NCT00980343 ·Status: COMPLETED ·Phase: PHASE2
-
Disease Progression and Treatment-induced Alterations in Glioblastoma
NCT02152748 ·Status: UNKNOWN
-
Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma
NCT02179086 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Cediranib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
NCT00662506 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma
NCT02861898 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Predicting Response Patterns to Treatment in Glioblastoma (GBM) Patients
NCT04219475 ·Status: SUSPENDED
-
Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial
NCT06319027 ·Status: RECRUITING ·Phase: PHASE2
-
Radiation Boost for Newly Diagnosed Glioblastoma Multiforme
NCT00376103 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
PTCs-based Precision Treatment Strategy on Recurrent High-grade Gliomas
NCT05473923 ·Status: ACTIVE_NOT_RECRUITING ·Phase: EARLY_PHASE1
-
A Study of MEDI-575 in Subjects With Recurrent Glioblastoma Multiforme
NCT01268566 ·Status: COMPLETED ·Phase: PHASE2
-
GC1118 in Recurrent Glioblastoma Patients With High EGFR Amplification
NCT03618667 ·Status: COMPLETED ·Phase: PHASE2
-
Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma
NCT01122901 ·Status: TERMINATED ·Phase: PHASE2
-
Trial of Hypofractionated Radiation Therapy for Glioblastoma
NCT02206230 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy of TRPP Therapy in Glioblastoma Multiforme
NCT05589961 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Cilengitide in Treating Patients Who Are Undergoing Surgery for Recurrent or Progressive Glioblastoma Multiforme
NCT00112866 ·Status: TERMINATED ·Phase: PHASE2
-
Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status
NCT00813943 ·Status: COMPLETED ·Phase: PHASE2
-
Assessment of Novel Metabolic Imaging Modalities as A Predictor Of Therapeutic EfficacyiIn Glioblastoma (GBM)
NCT06855628 ·Status: SUSPENDED ·Phase: PHASE2