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Role of T Follicular Helper Cells in Autoimmune Hemolytic Anemia (TFH in AIHA)

NCT02828670 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2024-07-15

No results posted yet for this study

Summary

T follicular helper (TFH) cells represent a T cell subset dedicated to the activation of B cells. They have been involved in the pathogenesis of autoimmune diseases in humans such as lupus and Sjögren disease. We recently showed that TFH are implicated in the activation of autoreactive B lymphocytes during ITP. Autoimmune hemolytic anemia (AIHA) is an autoimmune disease due to antibodies targeting red blood cells. To date, the role of TFH in the pathogenesis of AIHA is not known.

We hypothesize that AIHA is associated with an increase in the number and/or function of TFH, that could participate in the activation of autoreactive B lymphocytes.

Conditions

  • Autoimmune Hemolytic Anemia

Interventions

BIOLOGICAL

blood sample

PROCEDURE

spleen sample

Sponsors & Collaborators

  • Centre Hospitalier Universitaire Dijon

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-06-07
Primary Completion
2022-02-15
Completion
2022-02-15

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02828670 on ClinicalTrials.gov