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Children and Adult Hemophagocytic Syndrome (HLHa)

NCT02113917 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 204

Last updated 2025-11-20

No results posted yet for this study

Summary

Different study of HLHa patients :

* Diagnosis criteria, because criteria are based on pediatric genetic studies.
* Physiopathological studies: genetic studies have demonstrated the role of CD8+ cells, in particular because they have a genetic defect affecting their cytotoxic functions in HLH pediatric. the aim is to establish if the same defect is found in both some or in all of HLHa patients. If this is the case, to then establish whether hypomorphic genetic mutations are responsible.

Conditions

  • Hemophagocytic Syndrome

Interventions

BIOLOGICAL

Identification of biological markers

Sponsors & Collaborators

  • Laboratory of normal and pathological development Immune System - IFR 94 U768

    collaborator UNKNOWN

  • Reference Centre for Hereditary Immunodeficiency: CEREDIH

    collaborator UNKNOWN

  • URC-CIC Paris Descartes Necker Cochin

    collaborator OTHER

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Olivier Hermine, MD, PhD · Hopital Necker Enfants Malades, Assistance Publique des Hôpitaux de Paris

Eligibility

Min Age
2 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2016-01-31
Completion
2017-01-12

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02113917 on ClinicalTrials.gov