Pain Perception: Lidocaine Rate/Temp/Buffer

Summary

This study will collect data from multiple academic institutions. The primary objective for part A of this study is to determine the impact of anesthetic injection rate and temperature on pain perception during dermatologic procedures, and the objective for the part B of this study is to determine if buffering of the anesthetic solution alters pain perception.

This study is a pilot study designed to determine feasibility of these procedures.

Conditions

• Pain

Interventions

PROCEDURE

Slow, Room Temperature Injection

The room temperature local anesthetic agent will be administered by slow infiltration.

PROCEDURE

Rapid, Room Temperature Injection

The room temperature local anesthetic agent will be administered by rapid infiltration.

PROCEDURE

Slow, Warm Temperature Injection

The warmed local anesthetic agent will be administered by slow infiltration.

PROCEDURE

Rapid, Warm Temperature Injection

The warmed local anesthetic agent will be administered by rapid infiltration.

PROCEDURE

Buffered Injection

One side of the body will be randomized to receive an injection of the buffered agent, while the contralateral side will be assigned to receive an injection of the unbuffered anesthetic agent.

PROCEDURE

Non-Buffered Injection

One side of the body will be randomized to receive an injection of the buffered agent, while the contralateral side will be assigned to receive an injection of the unbuffered anesthetic agent.

DRUG

Lidocaine

Injectable lidocaine solution (Lidocaine Hydrochloride and Epinephrine)

DRUG

Buffer

Sodium Bicarbonate

Sponsors & Collaborators

• Northwestern University

  lead OTHER

Principal Investigators

• Murad Alam, MD · Northwestern University

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

89 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-06-30

Primary Completion

2025-01-31

Completion

2025-01-31

Countries

• United States

Study Locations