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Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

NCT02810704 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 18883

Last updated 2026-04-09

No results posted yet for this study

Summary

PEPPER is a randomized study comparing the three most commonly used anticoagulants in North America in patients who have elected to undergo primary or revision hip or knee joint replacement surgery. The anticoagulants being compared are enteric coated aspirin, low intensity warfarin, and rivaroxaban.

Conditions

Interventions

DRUG

Enteric Coated Aspirin

DRUG

Warfarin

DRUG

Rivaroxaban

Sponsors & Collaborators

  • Patient-Centered Outcomes Research Institute

    collaborator OTHER

  • University of Maryland, Baltimore

    collaborator OTHER

  • Brigham and Women's Hospital

    collaborator OTHER

  • Northwestern University

    collaborator OTHER

  • Medical University of South Carolina

    collaborator OTHER

  • Dartmouth-Hitchcock Medical Center

    lead OTHER

Principal Investigators

  • Vincent D Pellegrini, MD · Dartmouth-Hitchcock Medical Center

  • Carol A Lambourne, PhD · Dartmouth-Hitchcock Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-12-31
Primary Completion
2025-09-30
Completion
2025-09-30
FDA Drug
Yes

Countries

  • United States
  • Canada

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02810704 on ClinicalTrials.gov