MedTrace Logo

Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis

NCT02794506 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2016-06-09

No results posted yet for this study

Summary

Background:

Propolis is a natural resin made by bees from various plant sources. Propolis exerts antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and antidiabetic properties. The purpose of this study was to assess the adjunctive benefit of propolis supplementation in individuals with both chronic periodontitis and type 2 diabetes mellitus (T2DM) receiving scaling and root planing (SRP).

Methods:

A 6-month randomized blinded clinical trial comparing SRP with placebo (placebo+SRP group, n=26) or combined with a 6- month regimen of 400 mg oral propolis once daily (propolis+SRP group, n=26) was performed in patients with long-standing T2DM and chronic periodontitis. Treatment outcomes included hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), serum N€-(carboxymethyl) lysine (CML) and changes in periodontal parameters.

Conditions

Interventions

DRUG

Propolis

Propolis capsules was taken by the experimental group for 6 months after receiving scaling and root planing (SRP).

DRUG

Placebo

Placebo capsules was taken by the control group for 6 months after receiving scaling and root planing (SRP).

Sponsors & Collaborators

  • Mansoura University

    collaborator OTHER

  • Mohamed Anees

    lead OTHER

Principal Investigators

  • Hesham M. El-Sharkawy, Ass.Prof. · Mansoura University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
38 Years
Max Age
63 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-06-30
Primary Completion
2014-12-31
Completion
2015-03-31

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02794506 on ClinicalTrials.gov