Asian neTwork for Translational Research and Cardiovascular Trials ("ATTRaCT")

Summary

To build on Singapore's competitive advantages in advanced cardiac imaging, genetic and molecular studies to develop an integrated "one -stop" platform spanning from human to large and small animal models, dedicated to deepening the understanding of CV disease progression, discovery of new targets and repurposing of drugs.

Conditions

• Heart Failure

Interventions

OTHER

Cardiovascular Magnetic Resonance Imaging (CMRI)

CMRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create images; for about 1 hour. Several sets of images are needed. No injection of drug or dye will be used for this procedure.

OTHER

Electrocardiogram (ECG)

ECG is a non-invasive test used to detect any underlying heart conditions by measuring the electrical activity of the heart.

OTHER

Blood Sample Collection

Blood will be drawn for circulating biomarkers, which are measurable indicators of the severity or presence of the heart failure condition.

OTHER

Clinical Assessment

Check health status, blood pressure, heart rate, height and weight measured. In addition, subject will undergo a heart examination.

OTHER

Cardiovascular Ultrasound (CVUS)

To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help the investigators understand the type and severity of heart failure.

OTHER

Cognitive Test

To relate the presence and severity of cognitive impairment (CI) with simultaneously acquired advanced cardiovascular imaging characteristics and circulating biomarkers of cardiovascular function, inflammation and coagulation.

Sponsors & Collaborators

• Singapore General Hospital

  collaborator OTHER

• National University Hospital, Singapore

  collaborator OTHER

• Tan Tock Seng Hospital

  collaborator OTHER

• Khoo Teck Puat Hospital

  collaborator OTHER

• Changi General Hospital

  collaborator OTHER

• National Heart Centre Singapore

  lead OTHER

Principal Investigators

• Carolyn Lam, MBBS · National Heart Centre Singapore

Eligibility

Min Age

21 Years

Max Age

99 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-08-31

Primary Completion

2021-03-31

Completion

2021-03-31

Countries

• Singapore

Study Locations