Brain-heart Interactions in Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X:

Summary

The Tako-Tsubo Cardiomyopathy (TTC) and the Cardiac Syndrome X (CSX) are respectively acute and chronic heart diseases, which mimic myocardial infarction and stable angina pectoris without alterations of large coronary vessels. The causes and the most appropriate and best treatment for these diseases have not been yet clarified, but there are indications, that mental and psychosocial aspects may also contribute to these two diseases. So far, there is no study, which has comprehensively evaluated the interactions between mind and heart in these two conditions.

The purpose of this study is to search for possible differences in mental activity, response to stressful events and function of specific areas of the brain deeply involved in relation between mind and heart.

45 subjects will be recruited and divided equally into: patients with CSX, patients with TTC (at least 6 months ago) and patients with previous acute myocardial infarction (at least 6 months ago). All participants will undergo a clinical interview and several questionnaires that assess various mental functions, the stress response and the quality of life. In addition, in a separate visit the participants will undergo a Magnetic Resonance Imaging without contrast medium that helps to assess function of specific areas of the brain.

Conditions

• Takotsubo Cardiomyopathy
• Cardiac X Syndrome
• Acute Myocardial Infarction

Interventions

OTHER

Manual for the Assessment and Documentation of Psychopathology (AMDP 8)

OTHER

Million Clinical Multiaxial Inventory 3 (MCMI-III)

OTHER

State-Trait Anxiety Inventory form Y (STAI-Y)

OTHER

SF-36 Health-Related Quality of Life

OTHER

Blood oxygenation level dependent- functional Magnetic Resonance Imaging (BOLD-fMRI)

Sponsors & Collaborators

• Swiss Heart Foundation

  collaborator OTHER

• Ospedale San Giovanni Bellinzona

  lead OTHER

Principal Investigators

• Mattia Cattaneo, MD · Ospedale San Giovanni Bellinzona

• Augusto Gallino, MD · Ospedale San Giovanni Bellinzona

Study Design

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-02-29

Primary Completion

2017-11-30

Completion

2017-11-30

Countries

• Switzerland

Study Locations