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Perioperative Oral Steroids for Chronic Rhinosinusitis Without Polyps (CRSsNP)

NCT02748070 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 81

Last updated 2020-08-04

Study results available
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Summary

While oral steroids have been shown to be effective in the management of patients with chronic rhinosinusitis with polyps, its role in treating chronic rhinosinusitis without polyps (CRSsNP) is ambiguous. Despite a lack of strong clinical evidence to suggest a benefit in this disease state, steroids are often prescribed as a component of post-operative care after sinus surgery for patients without polyps. Oral steroids carry with them significant adverse effects, and should be prescribed thoughtfully. The aims of this study are to determine if oral steroids in the peri-operative period improves patient outcomes in CRS without polyps.

Conditions

  • Chronic Rhinosinusitis
  • Endoscopic Sinus Surgery
  • Chronic Rhinosinusitis Without Polyps
  • Oral Steroids

Interventions

DRUG

Prednisone

DRUG

Flonase

Sponsors & Collaborators

Principal Investigators

  • Julia E Noel, MD · Stanford University

  • Michael T Chang, MD · Stanford University

  • Peter H Hwang, MD · Stanford University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-08-31
Primary Completion
2019-07-15
Completion
2019-07-15

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02748070 on ClinicalTrials.gov