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Cryopreserved-thawed Embryo Transfer With or Without Gonadotropin Releasing Hormone Agonist

NCT02736032 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 310

Last updated 2018-05-17

No results posted yet for this study

Summary

Traditionally, the use of GnRH-a suppression was considered essential for adequate endometrial hormonal modulation in cryopreserved-thawed embryo transfer cycles. Several studies, however, have questioned its necessity for controlled endometrial preparation. Using a high dose of estradiol from day 1 of the cycle will suppress the gonadotroph, preventing folliculogenesis and excessive secretion of LH, allowing adequate endometrial preparation without GnRH-a.

Conditions

Interventions

PROCEDURE

Embryo transfer

The transfer of cryopreserved-thawed embryos inside the uterus aiming to achieve pregnancy

PROCEDURE

Serum Estradiol and Progesterone levels

Serum estradiol and serum progesterone levels in blood on the day of start of progesterone supplementation

DRUG

GnRH agonist

GnRH agonist given on day 21 of the cycle preceding the embryo transfer

DRUG

External Estradiol

Estradiol started on day1 of the cycle for endometrial prepartaion

DRUG

Progesterone

progesterone as luteal phase support start after endometrium is well prepared

Sponsors & Collaborators

  • Nile Ivf Center, Cairo, Egypt

    collaborator OTHER

  • Kamal Shaeer center of infertility

    collaborator UNKNOWN

  • Cairo University

    lead OTHER

Principal Investigators

  • Eman K Shaeer, MD · Cairo University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
35 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-03-31
Primary Completion
2018-05-31
Completion
2018-05-31

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02736032 on ClinicalTrials.gov