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Influence of Dietary Nitrate on Vascular Dysfunction and Inflammation

NCT02715635 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 78

Last updated 2022-07-20

No results posted yet for this study

Summary

The principal research objective is to determine whether inorganic nitrate in the form of beetroot juice compared to placebo control prevents the systemic inflammation that underlies typhoid vaccine-induced endothelial dysfunction

Conditions

Interventions

BIOLOGICAL

Typhoid vaccine

The typhoid vaccine is composed of purified polysaccharide from S. typhi capsule 25 micrograms contained in 0.5 ml solution

DIETARY_SUPPLEMENT

Concentrate beetroot Juice

140 ml containing \~8 mmol of inorganic nitrate

DIETARY_SUPPLEMENT

Concentrate beetroot Juice (Placebo)

140 ml which is nitrate-depleted

Sponsors & Collaborators

  • Queen Mary University of London

    lead OTHER

Principal Investigators

  • Amrita Ahluwalia, BSc PhD · William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine and Dentistry

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-04-30
Primary Completion
2020-12-31
Completion
2021-08-01

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02715635 on ClinicalTrials.gov