Efficacy and Safety of Wen Xin Granules for the Treatment of Unstable Angina Pectoris

Summary

This is a double-blind, randomized placebo-controlled trial which aims to evaluate the efficacy and safety of Wen Xin granule in patients with unstable angina pectoris.

Conditions

• Coronary Heart Disease
• Unstable Angina
• Chinese Herbal Medicine

Interventions

DRUG

Wen Xin granule

one dose daily, two times per day.

DRUG

Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet

one tablet daily. (for patients who can't use aspirin)

DRUG

Atorvastatin Calcium

20 mg tablet, one tablet each night.

DRUG

Isosorbide Mononitrate Tab 20 MG

one tablet， twice daily.

DRUG

Metoprolol Tartrate Tab 25 MG

12.5 mg or 25 mg, two times daily.

DRUG

Aspirin Enteric-coated Tablets

100mg tablet, one tablet daily.

DRUG

WXG placebo

one dose daily, two times per day.

DRUG

Trimetazidine Dihydrochloride Tablets

20 mg tablet, one tablet three times daily.

DRUG

glyceryl trinitrate

be taken when angina pectoris attacks.

Sponsors & Collaborators

• Special Project of National Traditional Chinese Medicine Clinical Research Base of State Administration of Traditional Chinese Medicine

  collaborator UNKNOWN

• National Natural Science Foundation of China

  collaborator OTHER_GOV

• Guang'anmen Hospital of China Academy of Chinese Medical Sciences

  lead OTHER

Principal Investigators

• Jun Li, M.D. · Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

35 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-03-01

Primary Completion

2023-03-01

Completion

2023-06-01