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Obstructive Sleep Apnoea in Children and Adolescents With Ehlers-Danlos Syndrome

NCT02712060 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2017-05-15

No results posted yet for this study

Summary

Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. EDS features such as genetically related cartilage defects, craniofacial abnormalities and increased pharyngeal collapsibility have been proposed to cause obstructive sleep apnoea (OSA). There is evidence from studies based on questionnaires that EDS patients might be more frequently affected by OSA and sleep disturbances than the general population. However, the actual prevalence of OSA in children and adolescents with EDS is unknown.

The primary objective of this study is to assess the prevalence of OSA in children and adolescents with EDS (25) compared to a matched control group (25). The secondary objective of this pioneer study is to assess the quality of life in children and adolescents in EDS in comparison to healthy children and adolescents.

Conditions

Interventions

OTHER

No intervention

Sponsors & Collaborators

  • University Children's Hospital, Zurich

    collaborator OTHER

  • Ehlers-Danlos Network, Switzerland

    collaborator OTHER

  • University of Zurich

    lead OTHER

Principal Investigators

  • Malcolm Kohler, MD · University of Zurich

Eligibility

Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-03-31
Primary Completion
2017-05-31
Completion
2017-05-31

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02712060 on ClinicalTrials.gov