MedTrace Logo

Obstructive Sleep Apnoea in Ehlers-Danlos Syndrome

NCT02435745 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2015-12-11

No results posted yet for this study

Summary

Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. EDS features such as genetically related cartilage defects, craniofacial abnormalities and increased pharyngeal collapsibility have been proposed to cause obstructive sleep apnoea (OSA). There is evidence from studies based on questionnaires that EDS patients might be more frequently affected by OSA and sleep disturbances than the general population. However, the actual prevalence of OSA in patients with EDS is unknown.

Aortic root dilation and dissection are common complications of EDS and little is known about the underlying risk factors. Preliminary evidence suggests a link with OSA but this has not yet been investigated.

The primary objective of this study is to assess the prevalence of OSA in EDS-patients (100) compared to a matched control group (100). The secondary objective of this pioneer study is to assess whether there is a relationship between OSA severity and aortic diame-ter/craniofacial abnormalities in EDS patients.

Conditions

Sponsors & Collaborators

  • University Children's Hospital, Zurich

    collaborator OTHER

  • Ehlers-Danlos Network, Switzerland

    collaborator OTHER

  • University of Zurich

    lead OTHER

Principal Investigators

  • Malcolm Kohler, Prof. MD · University of Zurich

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-04-30
Primary Completion
2015-12-31
Completion
2015-12-31

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02435745 on ClinicalTrials.gov