Donafenib Monotherapy for Previously Treated Metastatic Nasopharyngeal Carcinoma
NCT02698111 · Status: TERMINATED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2023-05-08
Summary
The investigators do the clinical trial (patients with metastatic nasopharyngeal carcinoma treated with donafenib after failure of standard therapy) to assess safety and efficacy of donafenib in patients with metastatic nasopharyngeal carcinoma, progressing after all approved standard therapies.
Conditions
- Nasopharyngeal Carcinoma
Interventions
- DRUG
-
Donafenib
donafenib 200mg,bid
Sponsors & Collaborators
-
Suzhou Zelgen Biopharmaceuticals Co.,Ltd
lead INDUSTRY
Principal Investigators
-
Yuan Kai Shi, Doctor · Cancer Hospital Chinese Academy of Medical Sciencess
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-02-08
- Primary Completion
- 2021-10-20
- Completion
- 2021-10-20
Countries
- China
Study Locations
More Related Trials
-
A Study Comparing BL-B01D1 With Physician's Choice of Chemotherapy in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma(PANKU-NPC01)
NCT06118333 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Phase Ⅱ Study of Neoadjuvant Chemotherapy Followed by Concurrent Chemoradiation for Stage Ⅲ Nasopharyngeal Carcinoma
NCT00816855 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of ZG006 in Participants With Small Cell Lung Cancer or Neuroendocrine Carcinoma
NCT05978284 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Trial Evaluating Maintenance Chemotherapy for Metastatic Nasopharyngeal Carcinoma
NCT02944708 ·Status: UNKNOWN ·Phase: PHASE3
-
Anti-PD1 Monoclonal Antibody Combined With Nimotuzumab and Capecitabine in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma
NCT06259721 ·Status: RECRUITING ·Phase: PHASE2
-
SHR-1210 in Recurrent/Metastatic Nasopharyngeal Carcinoma Who Have Received Previous At Least Two Lines of Chemotherapy.
NCT03558191 ·Status: COMPLETED ·Phase: PHASE2
-
Nab-TPC vs GP Combined With Camrelizumab in the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma
NCT06669611 ·Status: RECRUITING ·Phase: PHASE3
-
A Clinical Study to Evaluate the Efficacy and Safety of SI-B001 in the Treatment of Recurrent and Metastatic HNSCC
NCT05044897 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Phase Ⅱ Trial of Camrelizumab in Patients Without Distant Metastasis Nasopharyngeal Carcinoma
NCT04782765 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of Concurrent Chemotherapy and Radiotherapy for Stage II Nasopharyngeal Carcinoma
NCT00817258 ·Status: UNKNOWN ·Phase: PHASE2
-
SG2918 For Advanced Malignant Tumors
NCT06167486 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
PD-1 Blockade Combined With De-intensified Chemoradiotherapy Sparing Concurrent Cisplatin in Nasopharyngeal Carcinoma
NCT04907370 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Chemotherapy Combined With Radiotherapy vs Chemotherapy Alone for Distant Metastatic Nasopharyngeal Carcinoma
NCT02111460 ·Status: UNKNOWN ·Phase: PHASE3
-
Radiotherapy Combined With PD-1 Monoclonal Antibody and Capecitabine in the Treatment of Nasopharyngeal Carcinoma
NCT05290194 ·Status: RECRUITING ·Phase: PHASE2
-
Stop and go Strategy as First-line Treatment for Widely Metastatic Nasopharyngeal Carcinoma
NCT06331845 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
SBRT Combined With PD-1 Antibody and Chemotherapy in Oligometastatic Nasopharyngeal Carcinoma
NCT05524168 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Capecitabine Plus Toripalimab Maintenance Therapy in Metastatic Nasopharyngeal Carcinoma After First-line Treatment
NCT05484375 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Dose Escalation Study of ZG006 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma, Followed by Dose Expansion Study in Participants With Neuroendocrine Carcinoma.
NCT06440057 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Envafolimab Combined With Chemoradiotherapy and Recombinant Human Endostatin for LA-NPC.
NCT06059261 ·Status: RECRUITING ·Phase: PHASE2
-
Trial Evaluating Carbon Ion Radiotherapy With Concurrent Chemotherapy for Locally Recurrent Nasopharyngeal Carcinoma
NCT02801487 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma (NPC)
NCT00817583 ·Status: UNKNOWN ·Phase: PHASE2
-
Safety and Efficacy of NK510 to Treat NSCLC
NCT06097962 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Cadonilimab in the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma
NCT05898256 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
A Phase 3 Study of Donafenib in Patients With Radioiodine-refractory Differentiated Thyroid Cancer
NCT03602495 ·Status: TERMINATED ·Phase: PHASE3
-
Maintenance Therapy With Toripalimab Combined With Capecitabine/Placebo for Recurrent and Metastatic Nasopharyngeal Carcinoma
NCT05869227 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3