Trial Evaluating Maintenance Chemotherapy for Metastatic Nasopharyngeal Carcinoma

Summary

The purpose of this study is to examine the efficacy of maintenance chemotherapy for the treatment of metastatic nasopharyngeal carcinoma. Participants will be randomized to 3 arms. Arm 1, control group, participants will receive only 4-8 cycles of conventional chemotherapy; arm 2, participants will receive 6 cycles of maintenance chemotherapy after conventional chemotherapy; arm 3, experiment arm, after conventional chemotherapy, participants will receive maintenance chemotherapy until disease progression or intolerable toxicities.

Conditions

• Nasopharyngeal Carcinoma

Interventions

DRUG

Conventional chemotherapy

DRUG

Maintenance chemotherapy 1

DRUG

Maintenance chemotherapy 2

Sponsors & Collaborators

• Fudan University

  collaborator OTHER

• Eye & ENT Hospital of Fudan University

  collaborator OTHER

• The First Affiliated Hospital of Xiamen University

  collaborator OTHER

• Jiangxi Provincial Cancer Hospital

  collaborator OTHER

• Taichung Veterans General Hospital

  collaborator OTHER

• First Affiliated Hospital of Fujian Medical University

  collaborator OTHER

• Cancer Hospital of Guangxi Medical University

  collaborator OTHER

• National Cancer Centre, Singapore

  collaborator OTHER

• West China Hospital

  collaborator OTHER

• Peking University Cancer Hospital & Institute

  collaborator OTHER

• Tongji Hospital

  collaborator OTHER

• People's Hospital of Guangxi Zhuang Autonomous Region

  collaborator OTHER

• Shanghai Proton and Heavy Ion Center

  lead OTHER

Principal Investigators

• Jiade J Lu, MD · Shanghai Proton and Heavy Ion Center,Shanghai, SPHIC

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-10-31

Primary Completion

2018-10-31

Completion

2018-10-31

Countries

• China
• Singapore
• Taiwan

Study Locations