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Randomized Trial Comparing Performance of Molecular Markers for Indeterminate Thyroid Nodules

NCT02681328 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 328

Last updated 2025-12-22

No results posted yet for this study

Summary

The purpose of this study is to compare the performance of Afirma GSC and ThyroSeq v.3 in indeterminate thyroid nodules to determine which test can allow more patients to avoid unnecessary surgery and preserve quality of life. In the initial phase of this study, the performance of Afirma GEC and ThyroSeq v.2 were compared.

Conditions

  • Thyroid

Interventions

OTHER

Afirma GEC

Afirma GEC molecular test on collected thyroid tissue

OTHER

ThyroSeq v.2

ThyroSeq v.2 molecular test on collected thyroid tissue

OTHER

Afirma GSC

Afirma GSC molecular test on collected thyroid tissue

OTHER

ThyroSeq v.3

ThyroSeq v.3 molecular test on collected thyroid tissue

Sponsors & Collaborators

  • Jonsson Comprehensive Cancer Center

    lead OTHER

Principal Investigators

  • Masha Livhits, MC · Visiting Assistant Professor

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-05-01
Primary Completion
2026-12-01
Completion
2027-12-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02681328 on ClinicalTrials.gov