Sleep Abnormalities in Rare Genetic Disorders: AS, RTT, and PW

Summary

This study will investigate sleep behavior in subjects with Angelman Syndrome, Rett Syndrome or Prader-Willi Syndrome.

The study will also investigate sleep behavior in healthy siblings of subjects with Angelman Syndrome, Rett Syndrome or Prader-Willi Syndrome. These individuals will serve as control subjects.

The study will use questionnaires designed to identify sleep disorders and how they affect behavior and quality of life.

The principal goals of this study are:

1. To see how common sleep disorders are in individuals with Angelman Syndrome, Rett Syndrome or Prader-Willi Syndrome;
2. To see how sleep disorders affect behavior in these individuals;
3. To see whether sleep disorders and related behavior problems improve or worsen with age;
4. To see how specific disease conditions relate to sleep disorders and how bad the sleep disorders are;
5. To develop new treatment options to improve quality of life and behavior issues; and
6. To evaluate current treatment options to improve sleep problems in these individuals.

Conditions

• Rett Syndrome
• Prader-Willi Syndrome
• Angelman Syndrome
• Sleep Problems

Sponsors & Collaborators

• Boston Children's Hospital

  collaborator OTHER

• University of California, San Diego

  collaborator OTHER

• Greenwood Genetic Center

  collaborator OTHER

• University of Florida

  collaborator OTHER

• Vanderbilt University

  collaborator OTHER

• University of Kansas Medical Center

  collaborator OTHER

• University of California, Irvine

  collaborator OTHER

• University of Alabama at Birmingham

  collaborator OTHER

• Baylor College of Medicine

  lead OTHER

Principal Investigators

• Daniel Glaze, MD · Baylor College of Medicine

• Alan Percy, MD · University of Alabama at Birmingham

• Sanjeev Kothare, MD · Harvard Medical School, Children's Hospital Boston

Eligibility

Min Age

1 Year

Max Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2011-06-30

Primary Completion

2013-07-31

Completion

2013-07-31

Countries

• United States

Study Locations