Social Cognitive Assessment in Autism and Schizophrenia

Summary

In people with schizophrenia or people with autism, impairments of social cognition are a core feature of the disease and, according to researchers who represent valuable references on this subject for the international community, three to five processes of social cognition are usually altered in those diseases: (1) emotional processing which is the ability to identify emotions through facial expressions, gestures, and tone of voice, (2) theory of mind (ToM), which is defined as "the ability to attribute mental states (beliefs, intents, desires, …) to oneself and others, and to understand that others have beliefs, intentions, and desires that are different from one's own", (3) attributional style which refers to how people explain the causes of positive and negative events, and corresponding, in schizophrenia, to self-serving and personalizing bias that means a tendency to blame others for negative life events rather than sharing the responsibilities between different sources; and (4 and 5) social perception and knowledge, which can be defined as decoding and interpreting social cues from others, taking the social context into account, and knowing social rules, roles, and goals. Components of social cognition appear to be related to both symptomatology and functioning in everyday life. The present study aims to assess a new social cognitive battery developed by several teams in France: ClaCoS.

Conditions

• Schizophrenia

Interventions

BEHAVIORAL

schizophrenia

The battery (ClaCoS) is composed by 6 tests and several scores will be recorded for each: * for emotion perception : Facial emotions recognition task (TREF) * for theory of mind : Movie for the assessment of social cognition ( MASC-VF) * for attributional bias : Ambiguous Intentions Hostility Questionnaire ( AIHQ) * for social perception and knowledge : interpretation score - with and without index, comprehension score ( PerSo ) * for empathy :Questionnaire of cognitive and affective empathy ( QCAE) for people with schizophrenia * for self assessment : Self - assessment of social cognition (ACSo)

BEHAVIORAL

Autism

The battery (ClaCoS ) is composed by 6 tests and several scores will be recorded for each: * for emotion perception : Facial emotions recognition task(TREF ): total score, score per emotion, detection levels * for theory of mind : Movie for the assessment of social cognition (MASC ) :total score, error type * for attributional bias : Ambiguous Intentions Hostility Questionnaire (AIHQ) :hostility score, attribution score, aggression score * for social perception and knowledge : interpretation score - with and without index, comprehension score ( PerSo ) * for empathy : Empathy quotient (EQ) * for self assessment : Self - assessment of social cognition ( ACSo ): total score and scores per processes

BEHAVIORAL

Healthy controls

only social cognitive measures

Sponsors & Collaborators

• Hôpital le Vinatier

  lead OTHER

Principal Investigators

• FRANCK NICOLAS, PUPH · Service Universitaire de Réhabilitation - Le Vinatier Hospital

Study Design

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

45 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-12-04

Primary Completion

2021-03-31

Completion

2021-06-30

Countries

• France

Study Locations