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Augmented Pulse Pressure Variation to Predict Fluid Responsiveness in Open Laparotomy

NCT02653469 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 38

Last updated 2016-03-04

No results posted yet for this study

Summary

Pulse pressure variation (PPV) is a well-known and widely used dynamic preload indicator based on heart-lung interaction to predict fluid responsiveness. Generally, patients are considered to be fluid-responsive when the PPV value larger than 11-13%. However, several previous researches demonstrated that there is a zone of uncertainty (grey zone) in PPV. To predict fluid-responsiveness accurately in the patients with PPV within grey zone (9-13%), the investigators would evaluate the augmented PPV using augmented ventilation.

Conditions

  • Gynecologic Neoplasms
  • Abdominal Neoplasms

Interventions

OTHER

Augmented ventilation

When the patient's PPV is within grey zone, patient's tidal volume is maintained with augmented tidal volume of 12 ml/kg (from normal ventilation of 8ml/kg) for 2min duration.

OTHER

Fluid loading

We record the stroke volume index (SVI) values before and after volume expansion with 6ml/kg of balanced crystalloid

Sponsors & Collaborators

  • Samsung Medical Center

    lead OTHER

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-09-30
Primary Completion
2016-02-29
Completion
2016-02-29

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02653469 on ClinicalTrials.gov