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Staph Household Intervention for Eradication (SHINE)

NCT02572791 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 835

Last updated 2026-02-24

Study results available
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Summary

The investigators propose a pragmatic comparative effectiveness trial evaluating several decolonization strategies in patients with Staphylococcus aureus infection, their household contacts, and household environmental surfaces. The central hypothesis of this proposal is that an integrated approach of periodic personal and household environmental hygiene will reduce S. aureus transmission in households and subsequently decrease the incidence of skin and soft tissue infections (SSTI).

Conditions

  • Skin and Subcutaneous Tissue Bacterial Infections
  • Staphylococcus Aureus
  • MRSA - Methicillin Resistant Staphylococcus Aureus Infection

Interventions

DRUG

Chlorhexidine

DRUG

Mupirocin

BEHAVIORAL

Household cleaning

Sponsors & Collaborators

  • Washington University School of Medicine

    lead OTHER

Principal Investigators

  • Stephanie A Fritz, MD, MSCI · Washington University School of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-31
Primary Completion
2024-11-30
Completion
2024-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02572791 on ClinicalTrials.gov