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A Randomized Clinical Trial to Prevent Recurrent CA-MRSA Infection

NCT00560599 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 350

Last updated 2025-03-10

No results posted yet for this study

Summary

This clinical trial tests the hypotheses that 1) body decolonization of patients with recurrent community-associated (CA) MRSA infections and their household members and 2) environmental decolonization of the patients' households will significantly reduce the likelihood of recurrent CA-MRSA infection.

Conditions

  • Methicillin Resistant Staphylococcus Aureus Skin Infections

Interventions

DRUG

mupirocin and chlorhexidine

Mupirocin (Bactroban Nasal): twice a day for 7 days, apply one pea-sized amount of Bactroban Nasal ointment directly into one nostril and another pea-sized amount for the other nostril. Chlorhexidine (Hibiclens): once a day for 14 days, rinse body with chlorhexidine.

BEHAVIORAL

household cleaning and disinfection

Environmental cleaning with topical ethanol and laundering of clothes and linen.

DRUG

mupirocin, chlorhexidine, & household cleaning/disinfection

Mupirocin (Bactroban Nasal): twice a day for 7 days, apply one pea-sized amount of Bactroban Nasal ointment directly into one nostril and another pea-sized amount for the other nostril. Chlorhexidine (Hibiclens): once a day for 14 days, rinse body with chlorhexidine. Environmental cleaning with topical ethanol and laundering of clothes and linen.

Sponsors & Collaborators

  • Kaiser Permanente

    collaborator OTHER

  • loren g miller

    lead OTHER

Principal Investigators

  • Jared Spotkov, M.D. · Kaiser Permanente

  • Loren Miller, M.D., M.P.H. · Harbor-UCLA Medical Center (LABiomed)

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
FACTORIAL

Eligibility

Min Age
1 Month
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-04-30
Primary Completion
2012-02-29
Completion
2012-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00560599 on ClinicalTrials.gov