Premotor Cortex: A New Target for Stroke Motor Rehabilitation

Summary

The goal of the study is to determine the effect of repetitive transcranial magnetic stimulation (rTMS) over the premotor cortex on training-related improvements in motor performance and associated neural plasticity.

Conditions

• Stroke

Interventions

DEVICE

rTMS over Premotor Cortex (Contralateral Hemisphere)

* Location of rTMS: premotor cortex * Frequency of rTMS: 0.1 Hz * Time of rTMS: 50 milliseconds before the onset of movement-related EMG * Device: MagStim Super Rapid 2 Transcranial Magnetic Stimulator

DEVICE

rTMS over Premotor Cortex (Ipsilateral Hemisphere)

* Location of rTMS: premotor cortex * Frequency of rTMS: 0.1 Hz * Time of rTMS: 50 milliseconds before the onset of movement-related EMG * Device: Super Rapid 2 Transcranial Magnetic Stimulator

DEVICE

rTMS (Control 1)

* Location of rTMS: premotor cortex * Frequency of rTMS: 0.1 Hz * Time of rTMS: 400 milliseconds after the onset of movement-related EMG * Device: Super Rapid 2 Transcranial Magnetic Stimulator

DEVICE

rTMS (Control 2)

* Location of rTMS: somatosensory cortex * Frequency of rTMS: 0.1 Hz * Time of rTMS: 50 milliseconds before the onset of movement-related EMG * Device: Super Rapid 2 Transcranial Magnetic Stimulator

DEVICE

rTMS (Control 3)

* Location of rTMS: premotor cortex * Frequency of rTMS: 0.1 Hz * Time of rTMS: 50 milliseconds before the onset of movement-related EMG * Device: Super Rapid 2 Transcranial Magnetic Stimulator with Sham Coil

OTHER

Motor Training

During motor training, participants will quickly extend their hand at a pace of one extension every 5 seconds (0.2Hz) in response to an auditory cue.

Sponsors & Collaborators

• American Heart Association

  collaborator OTHER

• Emory University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-09-30

Primary Completion

2024-02-29

Completion

2024-02-29

Countries

• United States

Study Locations