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Deep Neuromuscular Block on Cytokines Release and Postoperative Delirium

NCT02507609 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2018-06-20

No results posted yet for this study

Summary

The purpose of the study is to determine the relationship between the degree of neuromuscular block, the release of cytokines and clinical outcomes in elderly patients undergoing orthopedic surgery. Investigators hypothesize that deep neuromuscular blockade decreases the release of cytokine and the incidence of postoperative delirium in elderly patients undergoing orthopedic surgery, compared with moderate neuromuscular blockade.

Conditions

  • Hip Fractures

Interventions

OTHER

Moderate neuromuscular blockade

TOF count is maintained to 1 to 2 by intermittent intravenous injection of rocuronium bromide 5 mg during operation

OTHER

Deep neuromuscular blockade

PTC is maintained to 1 to 2 degree by continuous infusion of rocuronium bromide intravenous route

Sponsors & Collaborators

  • Konkuk University Medical Center

    lead OTHER

Principal Investigators

  • Seong-Hyop Kim, M.D. · Konkuk University Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
FACTORIAL

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-09-08
Primary Completion
2018-04-26
Completion
2018-04-26

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02507609 on ClinicalTrials.gov