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Postoperative Delirium in Hip Arthroplasty Patients

NCT02323984 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 49

Last updated 2017-01-20

No results posted yet for this study

Summary

Identification of specific circulating microRNAs and microemboli formation (diagnosed by TC Doppler) in both delirious groups and nondelirious group will be our primary target. Delirium assessment through standardized questionnaires will be done at baseline (day of the surgery - pre operatory), immediately after surgery (in post anesthesia care unit) and then every 12 hours in Day 1 and Day2 after surgery. The investigators will use linear mixed models to describe the change patterns overtime, and compare differences at each time point. Inflammatory biomarkers will be explored overtime as well. The investigators will also explore age effect on cognitive function - cognitive reserve - based on the score of the cognitive test administered at baseline.

Conditions

  • Delirium
  • Postoperative Complications

Interventions

OTHER

miRNA Testing, Microemboli Monitoring, Delirium Assessment

Delirium assessment questionnaire and blood testing for miRNA will be done for all patients postoperatively, as well as BIS monitoring during surgery. The three arms of the study indicate the allocation of each patient based on their delirium presentation (hypoactive, hyperactive, or none).

Sponsors & Collaborators

  • Ohio State University

    lead OTHER

Principal Investigators

  • Fievos L Christofi, PhD · Ohio State University

Eligibility

Min Age
30 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2016-03-31
Completion
2016-03-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02323984 on ClinicalTrials.gov