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Role of Mesenchymal Stem Cells in Fat Grafting

NCT02494752 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2015-07-10

No results posted yet for this study

Summary

Contour deformity of face causes both functional as well as aesthetic problems for the patient. Fat being an autologous tissue source is considered as an ideal soft-tissue filler because it is abundant, readily available, inexpensive, host compatible, and can be harvested easily and repeatedly. However absorption of grafted fat is a major problem resulting in lack of consistency of final clinical outcome. Adipose tissue derived mesenchymal stem cells have the potential to enhance the viability of the grafted fat and the reliability of the final outcome of surgery. In the current study potential of mesenchymal stem cells will be studied by comparing two groups of patients requiring fat grafting for contour deformities of face. Control group will have fat graft with out enrichment with stem cells whereas experimental group will have their fat graft enriched with mesenchymal stem cells. Comparison will be made regarding viability of grafted fat in two groups.

Conditions

  • Romberg's Disease
  • Craniofacial Microsomia
  • Lipodystrophy
  • Mixed Connective Tissue Disease

Interventions

PROCEDURE

Fat graft enriched with ex vivo expanded stem cells

Fat graft will be enriched with ex vivo expanded stem cells

PROCEDURE

Fat graft not enriched with ex vivo expanded stem cells

Fat graft will not be enriched with ex vivo expanded stem cells

Sponsors & Collaborators

  • King Edward Medical University

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
16 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-08-31
Primary Completion
2016-02-29
Completion
2016-02-29

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02494752 on ClinicalTrials.gov