Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting

Summary

The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.

Conditions

• Romberg Disease
• Craniofacial Microsomia
• Burn Scar
• Post-Traumatic Scar (Disorder)

Interventions

BIOLOGICAL

Cultured ASCs enrichment fat grafting

Patients will undergo conventional fat harvesting. Harvested fat will be mixed with cultured ASCs and grafted into recipient site with 1,00,000 cells/ml injected fat

BIOLOGICAL

Curcumin-preconditioned ASCs enrichment fat grafting

Patients will undergo conventional fat harvesting. Harvested fat will be mixed with cultured ASCs preconditioned with curcumin and grafted into recipient site with 1,00,000 cells/ml injected fat

OTHER

Conventional fat grafting

Patients will undergo conventional fat harvesting and grafting of fat into recipient site

Sponsors & Collaborators

• Centre of Excellence in Molecular Biology, University of the Punjab, Lahore

  collaborator UNKNOWN

• Higher Education Commission (Pakistan)

  collaborator OTHER

• Jinnah Burn and Reconstructive Surgery Centre, Lahore

  collaborator OTHER_GOV

• University of the Punjab

  lead OTHER

Principal Investigators

• Azra Mehmood, PhD · Center of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore

• Sheikh Riazuddin, PhD · Jinnah Burn and Reconstructive Surgery Center (JB&RSC), Lahore

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-11-20

Primary Completion

2025-12-31

Completion

2025-12-31

Countries

• Pakistan

Study Locations