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Genetical, Anthropometrical and Biochemical Factors Influencing High Risk Subclinical Atherosclerosis

NCT02487615 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 340

Last updated 2015-07-07

No results posted yet for this study

Summary

Subclinical atherosclerosis is the atherosclerotic process identified before clinical symptoms and thus it can be a useful marker of future cardiovascular events. It can be evaluated by many methods. This study included the diagnosis of subclincal atherosclerosis by four different methods: coronary calcium score, carotid doppler ultrasound to quantify intima media thickness and carotid plaques, exercise stress test and ankle brachial index. Clinical data, anthropometric measures (body mass index, abdominal circumference), markers of inflammation (high sensitive - C reactive protein, TNF alfa and Lipoprotein Associated Phospholipase A2), fat tissue function (leptin, resistin and adiponectin), glucose metabolism (fasting plasma glucose, glycated hemoglobin and insulin) and genetics markers of atherosclerotic process were evaluated as biomarkers of subclinical atherosclerosis in a uneventful population.

Conditions

  • Primary Prevention

Sponsors & Collaborators

  • University of Campinas, Brazil

    collaborator OTHER

  • Instituto Dante Pazzanese de Cardiologia

    lead OTHER

Principal Investigators

  • Andriana Bertolami, MD, PhD · Instituto Dante Pazzanese de Cardiologia

  • Andrei C Sposito, MD, PhD · University of Campinas, Brazil

Eligibility

Min Age
25 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2013-03-31
Completion
2013-03-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02487615 on ClinicalTrials.gov