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Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients

NCT02466646 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2020-06-09

Study results available
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Summary

The purpose of this study is to determine whether full-mouth disinfection is effective in the initial periodontal treatment of generalized aggressive periodontitis on clinical parameters, gingival crevicular fluid interleukin-1β (IL-1β) and interleukin-17 (IL-17) and periodontal pathogen levels compared with conventional initial periodontal treatment and full-mouth initial periodontal treatment.

The investigators' hypothesis is to test whether full-mouth disinfection in the initial periodontal treatment of generalized aggressive periodontitis enhance the clinical, biochemical and microbiological parameters in comparison to conventional initial periodontal treatment and full-mouth initial periodontal treatment.

Conditions

  • Aggressive Periodontitis

Interventions

DRUG

Klorhex® Gel, rinse and spray

Initial periodontal treatment was performed in 2 sessions with application of chlorhexidine to the intra-oral niches within 24 hours (Klorhex® Gel 1% for 10 minutes, Klorhex® Spray 0,2% and Klorhex® rinse 0,2% for 3 weeks).

PROCEDURE

Conventional IPT

Initial periodontal treatment was performed in a quadrant-wise manner at 1-week intervals.

PROCEDURE

Full-mouth IPT

Initial periodontal treatment was performed in 2 sessions within 24 hours.

Sponsors & Collaborators

  • Marmara University

    lead OTHER

Principal Investigators

  • Basak Dogan, Prof. Dr. · Marmara University, Faculty of Dentistry, Department of Periodontology

  • Dilek Mamaklioglu, Dr. · Marmara University, Faculty of Dentistry, Department of Periodontology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-12-31
Primary Completion
2014-09-30
Completion
2014-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02466646 on ClinicalTrials.gov