Macronutrient Regulation of Ghrelin and Peptide YY

Summary

The hyperghrelinemia of children with PWS provides a unique model by which to explore the hormonal and metabolic effects of orexigenic hormones in normal and pathologic conditions. An important question to be addressed by this proposed research includes the macro-nutrient regulation of ghrelin and PYY in obese children and children with PWS. As ghrelin antagonists are considered potential future anti-obesity agents, it is essential to gain understanding of the developmental, nutritional and hormonal regulation of this important orexigenic hormone in children.

Conditions

• Obesity
• Prader Willi Syndrome

Interventions

OTHER

High carbohydrate meal

65% carbohydrate, 17% protein, and 18% fat

OTHER

High fat meal

58% fat, 17% protein, and 25% carbohydrate

Sponsors & Collaborators

• National Institutes of Health (NIH)

  collaborator NIH

• Canadian Institutes of Health Research (CIHR)

  collaborator OTHER_GOV

• Foundation for Prader-Willi Research

  collaborator OTHER

• Stollery Children's Hospital Foundation

  collaborator OTHER

• Alberta Diabetes Institute

  collaborator OTHER

• Sarah W. Stedman Nutrition and Metabolism Center

  collaborator UNKNOWN

• American Diabetes Association

  collaborator OTHER

• Duke Children's Miracle Network

  collaborator UNKNOWN

• National Center for Research Resources (NCRR)

  collaborator NIH

• Duke University

  lead OTHER

Principal Investigators

• Andrea Haqq, MD · University of Alberta

• Michael Freemark, MD · Duke University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

5 Years

Max Age

17 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2004-01-31

Primary Completion

2005-12-31

Completion

2005-12-31

Countries

• United States

Study Locations