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Alterations in the Brain's Connectome After Severe Traumatic Brain Injury

NCT02424656 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2023-09-13

No results posted yet for this study

Summary

This study explores the changes in whole-brain connectivity that occur during recovery from severe Traumatic Brain Injury and how these changes are related to the recovery of consciousness. Multimodal neuroimaging techniques will be used in a longitudinal fashion while patients are undergoing neurorehabilitation and after one-year of the TBI episode.

Conditions

Interventions

PROCEDURE

MRI

EEG-functional MRI, structural MRI, diffusion MRI

PROCEDURE

TMS-EEG

Single pulse TMS combined with EEG, resting-state EEG, noise masking (auditory stimulation), electrical stimulation

PROCEDURE

FDG-PET

OTHER

Clinical scales

Evaluation of DOC: Coma recovery scale-Revised (CRS-R) and Rancho Los Amigos Scale (RLAS). Evaluation of function: Functional Independent Measure (FIMTM), and Early Functional Assessment (EFA).

Sponsors & Collaborators

  • University of Milan

    collaborator OTHER

  • University of Kiel

    collaborator OTHER

  • Glostrup University Hospital, Copenhagen

    collaborator OTHER

  • Lundbeck Foundation

    collaborator OTHER

  • Danish Council for Independent Research

    collaborator OTHER

  • Region Capital Denmark

    collaborator OTHER

  • Danish Research Centre for Magnetic Resonance

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-09-30
Primary Completion
2021-09-30
Completion
2021-09-30

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02424656 on ClinicalTrials.gov