Routine and Deferred Dialysis Initiation

Summary

This study evaluates the efficacy and safety of deferred dialysis initiation in Chinese population. 16 tertiary hospitals across China will be randomly assigned into routine and deferred dialysis groups.

Conditions

• Chronic Kidney Disease

Interventions

OTHER

Algorithm for deferred dialysis intervention

Use combined indications to guide researchers to defer dialyzing progressive CKD patients. Asymptomatic patient will not start dialysis treatment until his eGFR becomes less than 5 ml/min/1.73m2. Or until 1. Patient's Kraemer index is \>6 or with overt fluid overload after trying all conservative means（including appropriate medicines） 2. Patient's Subjective Global Assessment method (SGA) assessment is grade C 3. Patients have indications for emergency dialysis 4. Sever symptoms which cannot be relieved by conservative treatment

OTHER

Algorithm for routine dialysis intervention

Use combined indications to guide researchers to initiate dialysis in progressive CKD patients routinely. Researchers will start dialysis treatment for a patient when his eGFR reaches 7 ml/min/1.73m2 in asymptomatic patients. Or patients have indications below: 1. Patient's Kraemer index is \>6 or with overt fluid overload after trying all conservative means（including appropriate medicines） 2. Patient's SGA assessment is grade C 3. Patients have indications for emergency dialysis 4. Sever symptoms which cannot be relieved by conservative treatment

Sponsors & Collaborators

• Peking University First Hospital

  collaborator OTHER

• Sichuan Academy of Medical Sciences

  collaborator OTHER

• First Affiliated Hospital of Zhejiang University

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Shaanxi Hospital of Traditional Chinese Medicine

  collaborator OTHER

• Peking Union Medical College Hospital

  collaborator OTHER

• Shengjing Hospital

  collaborator OTHER

• The First Affiliated Hospital of BaoTou Medical College

  collaborator OTHER

• Beijing Hospital, National Center of Gerontology

  collaborator UNKNOWN

• Beijing Haidian Hospital/Beijing Haidian Section of Peking University Third Hospital

  collaborator UNKNOWN

• Beijing Tongren Hospital

  collaborator OTHER

• Xuanwu Hospital, Beijing

  collaborator OTHER

• First Hospital of China Medical University

  collaborator OTHER

• Hangzhou Hospital of Traditional Chinese Medicine

  collaborator OTHER

• Ruijin Hospital

  collaborator OTHER

• Peking University People's Hospital

  lead OTHER

Principal Investigators

• Li Zuo · Peking University People's Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-07-31

Primary Completion

2020-08-31

Completion

2020-12-31

Countries

• China

Study Locations