Evaluation of Breathing, Sleep and the Effects of Continuous Positive Airway Pressure During Wakefulness in Children With Heart Failure

Summary

Adult patients with heart failure (HF) have an increased work of breathing and are at increased risk for obstructive and/or central apnea during sleep. Noninvasive continuous positive airway pressure (CPAP) has proved its efficacy in decreasing the work of breathing and improving sleep-disordered breathing in these patients.

The aim of the study is to analyze the work of breathing and objective and subjective sleep quality in children with HF and to evaluate the ability of noninvasive CPAP to decrease the work of breathing and improve cardiac output during wakefulness.

Conditions

• Heart Failure

Interventions

OTHER

Effect of CPAP on respiratory work and cardiac function indices during wakefulness

Comparison of three periods of 3 hours 1. st period: Spontaneous breathing for 10 minutes 2. nd period: CPAP for 10 minutes 3. rd period: Spontaneous breathing for 10 minutes to check the return to baseline. After each period, the following parameters will be recorded during 5 minutes: * oesogastric pressures * air flow * gas exchange * right and left cardiac function Patients \> 6 years old will assess their dyspnea on a visual analogue scale

OTHER

Effect of CPAP on respiratory work and cardiac function indices during wakefulness

Comparison of three periods of 3 hours 1. st period: Spontaneous breathing for 10 minutes 2. nd period: CPAP for 10 minutes 3. rd period: Spontaneous breathing for 10 minutes to check the return to baseline. After each period, the following parameters will be recorded during 5 minutes: * oesogastric pressures * air flow * gas exchange * right and left cardiac function Patients \> 6 years old will assess their dyspnea on a visual analogue scale

OTHER

Effect of CPAP on respiratory work and cardiac function indices during wakefulness

Comparison of three periods of 3 hours 1. st period: Spontaneous breathing for 10 minutes 2. nd period: CPAP for 10 minutes 3. rd period: Spontaneous breathing for 10 minutes to check the return to baseline. After each period, the following parameters will be recorded during 5 minutes: * oesogastric pressures * air flow * gas exchange * right and left cardiac function Patients \> 6 years old will assess their dyspnea on a visual analogue scale

DEVICE

CPAP

Sponsors & Collaborators

• Philips Healthcare

  collaborator INDUSTRY

• URC-CIC Paris Descartes Necker Cochin

  collaborator OTHER

• Assistance Publique - Hôpitaux de Paris

  lead OTHER

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

8 Months

Max Age

17 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-07-10

Primary Completion

2017-07-30

Completion

2017-07-30

Countries

• France

Study Locations