Long Term Oral Appliance Therapy Effectiveness for Obstructive Sleep Apnea Syndrome

Summary

Obstructive sleep apnea (OSA) is a highly prevalent breathing problem that occurs during sleep. OSA have been associated with the obesity epidemic in developing countries; additionally, high OSA prevalence rates are present in populations with cardiovascular and metabolic disorders. Two OSA treatments are currently available, oral appliance (OA) therapy and continuous positive airway pressure (CPAP). OAs are an underutilized non-surgical treatment and few studies have analyzed their long-term effectiveness for patients with OSA. The purpose of this study is to assess the long-term effectiveness of OA therapy in patients with OSA and to explore any changes on cardiovascular related morbidity and mortality related to this therapy.

Conditions

• Obstructive Sleep Apnea

Interventions

DEVICE

Oral Appliance

Mandibular Advancement Splints

Sponsors & Collaborators

• Universiteit Antwerpen

  collaborator OTHER

• University of Sydney

  collaborator OTHER

• University Hospital, Angers

  collaborator OTHER_GOV

• University of Groningen

  collaborator OTHER

• Université de Montréal

  collaborator OTHER

• Kaiser Permanente

  collaborator OTHER

• Stanford University

  collaborator OTHER

• Laval University

  collaborator OTHER

• University of Cambridge

  collaborator OTHER

• Kyushu University

  collaborator OTHER

• Japan Somnology Center, Neuropsychiatric Research Institute

  collaborator UNKNOWN

• Uniformed Services University of the Health Sciences

  collaborator FED

• University of British Columbia

  lead OTHER

Principal Investigators

• Fernanda Almeida, DDS,Phd · University of British Columbia

Eligibility

Min Age

18 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-04-01

Primary Completion

2026-09-30

Completion

2026-09-30

Countries

• Canada

Study Locations