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Treatment of Cartilage Defects With Peripheral Blood Stem Cells

NCT04953572 · Status: UNKNOWN · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 252

Last updated 2021-07-08

No results posted yet for this study

Summary

Knee joint cartilage cells metabolize slowly, and it is difficult to repair themselves after injury. Any knee joint trauma or the progression of osteoarthritis may lead to the progression of cartilage or osteochondral defects. Compared with bone marrow mesenchymal stem cells (MSCs), peripheral blood MSCs have better chondrogenic differentiation ability. At the same time, the mobilization of peripheral blood MSCs and the advancement of extraction technology also make it feasible to treat osteochondral damage by using peripheral blood MSCs. The purpose of this study is to evaluate the therapeutic effect of surgical transplantation of autologous peripheral blood MSCs to repair knee joint Ⅳ-degree localized cartilage injury, and to explore a new treatment for osteochondral defects based on the foundation of the research group's previous research.

Conditions

  • Cartilage Injury

Interventions

GENETIC

autologous peripheral blood mesenchymal stem cell

Transplantation of autologous peripheral blood mesenchymal stem cell

PROCEDURE

Microfracture

Microfracture

COMBINATION_PRODUCT

Microfracture + collagen membrane

Microfracture plus collagen membrane transplantation

PROCEDURE

Autologous osteochondral transplantation

Autologous osteochondral transplantation

Sponsors & Collaborators

  • Inner Mongolia People's Hospital

    collaborator OTHER

  • Hebei Medical University Third Hospital

    collaborator OTHER

  • Tianjin Hospital

    collaborator OTHER

  • Peking University Third Hospital

    lead OTHER

Principal Investigators

  • Jia-kuo Yu, Prof. · Peking University Third Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-01
Primary Completion
2023-12-31
Completion
2023-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04953572 on ClinicalTrials.gov