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The Role of Myocardial Fibrosis in Degenerative Mitral Regurgitation

NCT02355418 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 147

Last updated 2022-03-14

No results posted yet for this study

Summary

This study investigates the hypothesis that diffuse interstitial cardiac fibrosis develops in response to chronic volume overload from severe degenerative mitral regurgitation. The investigators will investigate the functional (exercise) and symptomatic (PROMS) outcomes of patients with severe but asymptomatic mitral regurgitation who have the option of choosing surgical repair or watchful waiting.

Conditions

  • Mitral Valve Regurgitation
  • Mitral Regurgitation

Interventions

PROCEDURE

Mitral valve repair

Standard mitral valve repair surgery

Sponsors & Collaborators

  • British Heart Foundation

    collaborator OTHER

  • University Hospital Birmingham NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Richard Steeds · University Hospital Birmingham

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-09-30
Primary Completion
2019-03-31
Completion
2019-03-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02355418 on ClinicalTrials.gov