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The Role of Chronotropic Incompetence in Heart Failure With Normal Ejection Fraction (HFNEF)

NCT02354573 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 121

Last updated 2015-02-04

No results posted yet for this study

Summary

What is heart failure with normal ejection fraction? The heart contracts (pumps) and relaxes with each heartbeat. In some people with heart failure, the heart contracts normally but there is reduced relaxation of the heart. As a result, people notice a feeling of breathlessness, ankle swelling and fatigue especially on exertion.

The investigators feel that patients with reduced or impaired relaxation of the heart have less heart filling time and poor energy utilisation during exercise. Therefore, the investigators are conducting a study to more thoroughly understand the disease condition by giving a drug called ivabradine to reduce the heart rate and hence to increase the heart filling time in these patients.

Conditions

Interventions

DRUG

Ivabradine

All subjects will receive Ivabradine 7.5mg twice daily for 2 weeks in a double-blind randomized crossover design.

Sponsors & Collaborators

  • University of Aberdeen

    collaborator OTHER

  • University of Oxford

    lead OTHER

Principal Investigators

  • Houman Ashrafian, MRCP · University of Oxford

Study Design

Allocation
RANDOMIZED
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-12-31
Primary Completion
2014-01-31
Completion
2014-01-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02354573 on ClinicalTrials.gov