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Chronic Fatigue Following Acute Epstein-Barr Virus Infection in Adolescents

NCT02335437 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 270

Last updated 2017-06-28

No results posted yet for this study

Summary

Chronic fatigue syndrome (CFS) is characterized by unexplained, disabling and long lasting fatigue, as well as pain, impaired memory, sleep difficulties and other symptoms. Epstein-Barr virus (EBV) infection might precipitate CFS. In this study, 200 adolescents undergoing acute EBV infection will be followed prospectively, and also compared with a group of healthy controls. The aim is twofold:

* To identify factors that predispose to chronic fatigue among adolescents with acute EBV infection
* To compare pathophysiological features of patients with acute EBV infection with a group of healthy controls.

Possible risk factors for chronic fatigue 6 months after EBV-infection includes:

* Severity of the initial infection
* Immune responses characteristics
* Characteristics of the neuroendocrine stress response
* Cognitive functioning
* Emotional disturbances
* Genetics/ epigenetics of candidate genes
* Certain personality traits
* Critical life events

Conditions

  • Fatigue Syndrome, Chronic
  • Epstein-Barr Virus Infections

Sponsors & Collaborators

  • University Hospital, Akershus

    lead OTHER

Principal Investigators

  • Vegard B Wyller · University Hospital, Akershus

Eligibility

Min Age
12 Years
Max Age
20 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-03-31
Primary Completion
2016-12-31
Completion
2017-06-30

Countries

  • Norway

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02335437 on ClinicalTrials.gov