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Effect of Genetic Association With Functional Dyspepsia and Mood Disorders

NCT02282995 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 1200

Last updated 2017-04-25

No results posted yet for this study

Summary

Background:

Functional dyspepsia (FD) is one of the commonest digestive disorders. The pathophysiology of functional dyspepsia is uncertain. Risk factors include genetics, gender, age, helicobacter pylori infection, etc. However, few reported the association of genetic contribution to the development of FD and mood disorder.

Indication:

Functional dyspepsia patients

Study center(s):

Prince of Wales Hospital, Hong Kong

Aims:

* To evaluate genetic factors on development of functional dyspepsia \& common mood disorders
* To evaluate genetic factors on the severity of function dyspepsia \& mood disorders
* To develop a diagnostic test for classification of functional dyspepsia by plasma ghrelin and serotonin expression
* To collect sleep data for future use
* To save blood sample for future retrospective diagnostic or genetic examination

Study design:

Case-control cross sectional study

Number of subjects:

Total of 1200 subjects (300 FD patients + 300 relatives of FD patients FDR) and (300 Controls + 300 FDR)

Patient population:

Functional dyspepsia patients age 18-60

Duration of study:

1 May 2012 - 30 April 2013

Primary variable(s):

Genetic polymorphisms of targeted genes, plasma ghrelin and serotonin expression

Secondary variable(s):

FD global symptom assessment and symptom scores

Number of visits: 1

Hypotheses:

* Shared genetic factors contribute to the development of FD and common psychological disorders
* FD patients contribute to suppression of plasma ghrelin and serotonin expression compared to healthy controls

Conditions

  • Dyspepsia

Sponsors & Collaborators

  • Chinese University of Hong Kong

    lead OTHER

Principal Investigators

  • Justin C.Y. Wu, MBChB(CUHK) · Chinese University of Hong Kong

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-08-31
Primary Completion
2017-12-31
Completion
2017-12-31

Countries

  • Hong Kong

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02282995 on ClinicalTrials.gov