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Mucosal Barrier Defects in Functional Dyspepsia by Confocal Laser Endomicroscopy

NCT01006642 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2009-11-03

No results posted yet for this study

Summary

There has been recent interest into the potential role of mucosal barrier defects in the pathophysiology of functional gastrointestinal disorders (FGIDs). There has been evidence of increased intestinal permeability in patients of IBS,and abnormal tissue resistance in NERD. Although the mucosa of Functional dyspepsia (FD) patients is endoscopically and histologically "normal," it contains ultrastructural changes, activated immune cells, along with evidence of an increased release of mediators leading to gastric dysfunction. There is now consistent evidence indicating that mucosal barrier defects allow the passage of an increased load of bacteria, antigens and toxins which, in turn evoke activation of mucosal immune responses involved in the FD symptom.

Conditions

  • Functional Dyspepsia

Sponsors & Collaborators

  • Shandong University

    lead OTHER

Principal Investigators

  • Yanqing Li, PhD. MD. · Department of Gastroenterology, Qilu Hospital

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-07-31
Primary Completion
2010-03-31
Completion
2010-07-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01006642 on ClinicalTrials.gov