Prehospital Resuscitation On Helicopter Study

Summary

The Prehospital Resuscitation On Helicopter Study (PROHS) is a pragmatic, multicenter, prospective observational study of air ambulance-based prehospital resuscitation regimens currently utilized at the participating sites. Patients will be enrolled at participating sites that currently have blood products available on air ambulances and other sites that do not. This study will not change the current prehospital standard of care for resuscitation. The primary outcome will be in-hospital mortality and the primary unit of analysis will be the patient. Other outcomes of interest will include time to hemostasis, hospital length-of-stay, number of ventilator-free and ICU-free days, incidence of major surgical procedures, complications (transfusion-related acute lung injury \[TRALI\], acute kidney injury \[AKI\], multiple organ failure \[MOF\], acute respiratory distress syndrome \[ARDS\], sepsis, intra-abdominal complications, thromboembolic complications, compartment syndromes), lifesaving interventions, the amount and type of blood products and concentrates transfused (including prehospital), wastage of prehospital blood products and concentrates, use of external and internal hemostatic devices, and functional status at discharge/discharge destination.

Conditions

• Traumatic Injuries

Interventions

OTHER

No intervention

Observational study

Sponsors & Collaborators

• University of Cincinnati

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• Oregon Health and Science University

  collaborator OTHER

• University of Washington

  collaborator OTHER

• University of Maryland

  collaborator OTHER

• University of Alabama at Birmingham

  collaborator OTHER

• University of Arizona

  collaborator OTHER

• University of Southern California

  collaborator OTHER

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Resuscitation Outcomes Consortium

  collaborator NETWORK

• The University of Texas Health Science Center, Houston

  lead OTHER

Principal Investigators

• John Holcomb, M.D. · The University of Texas Health Science Center, Houston

Eligibility

Min Age

15 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-01-31

Primary Completion

2015-12-31

Completion

2015-12-31

Countries

• United States

Study Locations