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Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen

NCT02243254 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2015-11-18

No results posted yet for this study

Summary

Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia

Conditions

  • Ibuprofen
  • Remifentanil
  • Hyperalgesia
  • Pain, Postoperative

Interventions

DRUG

high dose remifentanil

high dose remifentanil

DRUG

Ibuprofen

intravenous ibuprofen

DRUG

low dose remifentanil

low dose remifentanil

Sponsors & Collaborators

  • Seoul National University Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-07-31
Primary Completion
2015-04-30

Countries

  • South Korea

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02243254 on ClinicalTrials.gov