Treatment for Teens With Alcohol Abuse and Depression

Summary

The investigators will recruit adolescents with alcohol or cannabis abuse and clinically significant depression. All participants will receive 12 sessions of an evidence-based treatment for alcohol abuse, Motivation Enhancement Therapy/Cognitive Behavior Therapy-12, over 12 to 14 weeks. Those who are still depressed after 4 weeks will be randomized to receive treatment augmentation with either an integrated cognitive behavior therapy for depression, delivered by their study therapist, or depression treatment-as-usual in the community. The study hypothesis is that integrated depression treatment will surpass community treatment-as-usual in efficacy.

Conditions

• AOD Use, Abuse, and Dependence
• Depression

Interventions

BEHAVIORAL

MET/CBT-12

Two sessions of motivation enhancement therapy followed by 10 sessions of cognitive behavior therapy targeting alcohol or cannabis abuse. These 12 sessions will be delivered over 12 to 14 weeks.

BEHAVIORAL

CBT-D

CBT-D consists of seven weekly sessions of cognitive behavior therapy targeting depression.

OTHER

D-TAU

D-TAU is treatment as usual in the community, targeting depression. It may consist of medication and/or behavioral intervention.

Sponsors & Collaborators

• UConn Health

  collaborator OTHER

• National Institute on Alcohol Abuse and Alcoholism (NIAAA)

  collaborator NIH

• Duke University

  lead OTHER

Principal Investigators

• John F Curry, PhD · Duke University

• Yifrah Kaminer, M.D. · UConn Health

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

13 Years

Max Age

263 Months

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-01-16

Primary Completion

2020-01-03

Completion

2020-01-03

Countries

• United States

Study Locations